These suggestions for the betterment and elucidation of the text of the De Beneficiis are additional to those already published in the Classical Quarterly in January, 1934. They are based on a conviction much deepened since that time that Buck1 is right when he says: N allein, und zwar ohne seine Ueberarbeitungen von späteren Händen, darf die Grundlage des Textes von de beneficiis bilden. Préchac3, the latest critical editor in this field, substantially confirms Buck's sweeping conclusion by an independent survey (...) of the evidence. The readings designated in the Teubner text3 as N2 and N3 are themselves conjectures, not readings drawn from independent sources of testimony, and as conjectures they must be judged. Gertz4 had long before discerned the truth even if he seemed somewhat cavalier in his attitude toward other manuscripts than N. (shrink)

The scope and length of this anthology make it one of the best recent introductions to Continental thought for the English-speaking reader. Despite the editor's efforts to compass a century and a half of European thought under the somewhat inflated title of a "search for being," each of the fourteen contributors is allowed enough space to show that no single problem or quest concretely typifies European philosophical activity in our time. If one overlooks the dramatic cutting and pasting required by (...) the attempt to give an existential flavor to the thinkers, one finds the merit of the book to be precisely the inclusion of authors whose interests are in important respects quite divergent from those of the existentialists. There are new, long translations from Schelling, Ravaisson, Lachelier, Simmel, Husserl, and Heidegger. There is a selected bibliography.--W. H. C. (shrink)

The recent discussions about alternative sources of human embryonic stem cells , while stirring new interest in the developmental potential of the various abnormal embryos or constructs proposed as such sources, also raise questions about the potential of the derived embryonic stem cells. The data on the developmental potential of embryonic stem cells that seem relevant for ethical considerations and aspects of patentability are discussed. Particular attention is paid to the meaning of “totipotency, omnipotency and pluripotency” as illustrated by a (...) comparison of the developmental potential of three-dimensional clusters of blastomeres , embryonic stem cells, somatic or stem cells or other somatic cells. This paper focuses on embryoid bodies and on direct cloning by tetraploid complementation. Usage and patenting of these cells cannot be considered to be ethically sound as long as totipotency and tetraploid complementability of embryonic stem cells are not excluded for the specific cell line in question. Testing this poses an ethical problem in itself and needs to be discussed in the future. (shrink)

A good edition of the Catalepton has long been wanted: and Birt's recently Published ‘Erklärung,’ despite some obvious defects, may fairly be regarded as good book. It is at any rate fresh, interesting, and stimulating. The text is the whole, though not always, sensible. The commentary is full without being too full. But, more valuable still, both commentary and introduction constantly bring home to one the probability that nearly all the poems in this collection are genuinely Vergilian— ‘Jugendverse und (...) Heimatpoesie Vergils.’ No editor before Birt has brought before us so clearly the environment out of which these poems came. (shrink)

In the past two decades, reinforcement learning has become a popular framework for understanding brain function. A key component of RL models, prediction error, has been associated with neural signals throughout the brain, including subcortical nuclei, primary sensory cortices, and prefrontal cortex. Depending on the location in which activity is observed, the functional interpretation of prediction error may change: Prediction errors may reflect a discrepancy in the anticipated and actual value of reward, a signal indicating the salience or novelty of (...) a stimulus, and many other interpretations. Anterior cingulate cortex has long been recognized as a region involved in processing behavioral error, and recent computational models of the region have expanded this interpretation to include a more general role for the region in predicting likely events, broadly construed, and signaling deviations between expected and observed events. Ongoing modeling work investigating the interaction between ACC and additional regions involved in cognitive control suggests an even broader role for cingulate in computing a hierarchically structured surprise signal critical for learning models of the environment. The result is a predictive coding model of the frontal lobes, suggesting that predictive coding may be a unifying computational principle across the neocortex. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

It has long been recognized that cancer onset and progression represent a type of reversion to an ancestral quasi‐unicellular phenotype. This general concept has been refined into the atavistic model of cancer that attempts to provide a quantitative analysis and testable predictions based on genomic data. Over the past decade, support for the multicellular‐to‐unicellular reversion predicted by the atavism model has come from phylostratigraphy. Here, we propose that cancer onset and progression involve more than a one‐off multicellular‐to‐unicellular reversion, and (...) are better described as a series of reversionary transitions. We make new predictions based on the chronology of the unicellular‐eukaryote‐to‐multicellular‐eukaryote transition. We also make new predictions based on three other evolutionary transitions that occurred in our lineage: eukaryogenesis, oxidative phosphorylation and the transition to adaptive immunity. We propose several modifications to current phylostratigraphy to improve age resolution to test these predictions. Also see the video abstract here: https://youtu.be/3unEu5JYJrQ. (shrink)

This article reconstructs Nietzsche's shifting views on democracy in the period 1870–86 with reference to his enduring preoccupation with tyrannical concentrations of power and the conviction that radical pluralism offers the only effective form of resistance. As long as he identifies democracy with pluralism , he sympathizes with it as a site of resistance and emancipation. From around 1880 on, however, Nietzsche increasingly links it with tyranny, in the form of popular sovereignty, and with the promotion of uniformity, to (...) the exclusion of genuine pluralism. Democracy's emancipatory claims are reinterpreted as "misarchism," or hatred of authority, and Nietzsche looks to the "exceptional beings" excluded by democracy for sources of resistance to the "autonomous herd" and "mob rule." Against elitist readings of this move, it is argued that Nietzsche opposes the domination of the herd type under democracy from a standpoint in human diversity and a generic concern with the future of humankind. Exceptional individuals are conceived in pluralistic, agonal terms, as a community of legislators engaged in a process of transvaluation that serves the interests not of one or a few but of all of us: "the self-overcoming of the human.". (shrink)

The significance of the dating of Enmann's Kaisergeschichte in the controversy which has long surrounded the Historia Augusta is common knowledge to all scholars who have more than a nodding acquaintance with the period. Enmann himself concluded that the KG ended with or shortly after Diocletian's accession. This was a necessary hypothesis for Enmann in 1884 because the H.A. had clearly used the KG and the self-proclaimed authorship and dating of the former were generally accepted. None the less in (...) Enmann's opinion the resemblances between Victor and Eutropius continued into the sole reign of Constantius II down to the Battle of Strasbourg in 357 and Enmann was compelled to ascribe this to a ‘continuation’ of the KG. (shrink)

This interview study investigates the short- and long-term implications of incidental findings detected through brain imaging on research participants’ lives and their surroundings. For this study, nine participants of the Rotterdam Scan Study with an incidental finding were approached and interviewed. When examining research participants’ narratives on the impact of the disclosure of incidental findings, the authors identified five sets of tensions with regard to motivations for and expectations of research participation, preferences regarding disclosure, short- and long-term impacts (...) and impacts on self and others. The paper shows: that the impact of incidental findings may be greater than participants at first let on; incidental findings can have significant effects on participants’ social environment; and participants may not feel prepared for disclosure even if incidental findings have been discussed during the informed consent process. The authors call for investigators to be aware of research participants’ experiences and these short- and long-term impacts when designing suitable courses of action for the detection and management of incidental findings in research settings. (shrink)

Applied Christian Ethics addresses selected themes in Christian social ethics. Part one shows the roots of contributors in the realist school; part two focuses on different levels of the significance of economics for social justice; and part three deals with both existential experience and government policy in war and peace issues.

This volume illustrates the central importance of diversity of human values throughout healthcare. The readings are organized around the main stages of the clinical encounter from the patient's perspective. They run from staying well and 'first contact' through to either recovery or to long-term illness, death and dying.

The recent high-profile financial difficulties of Harvard Pilgrim Health Care, the largest HMO in Massachusetts and consistently rated as one of the top ten HMOs in the nation, shed light on many problems common to health insurers throughout the country. This article explores those difficulties in the context of the short but complicated history of Harvard Pilgrim, and its regulatory and competitive environments. The state legislation which made a receivership proceeding possible for Harvard Pilgrim offered some protection for subscribers, but (...) failed to provide the means for achieving a long term solution. The statute merely presented a method for staving off immediate collapse by temporarily protecting the plan from dissolution, and forcing the plan's contracting providers to continue delivering care even if owed money by the plan. The article concludes by drawing lessons for understanding and ideally avoiding similar managed care nearfatalities in the future. (shrink)

Depression is theorized to be caused in part by biased cognitive processing of emotional information. Yet, prior research has adopted a reductionist approach that does not characterize how biases i...

Too many patients are injured in the course of care. Clinicians may mistakenly cause new harm to a patient or fail to take established steps to improve the presenting condition. Medical institutions within which they work may lack mechanisms to reduce errors or prevent them from harming patients. Many, perhaps even most, injuries are preventable, probably numbering in the hundreds of thousands a year for hospital care alone. Long ignored by medical practitioners and health-care payers and little appreciated by (...) the public, the problem of medical injury is finally receiving high-level policy attention. Much credit goes to the Institute of Medicine for its landmark report of November 1999, which marshaled the evidence about medical injuries and highlighted new approaches to systematic improvement of safety within systems of care. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Perloff’s Wittgenstein: W(h)ither Poetic Theory?David Kellogg (bio)Though Marjorie Perloff has been one of the most powerful forces in contemporary poetry studies for some time, her work has not received the critical attention it warrants. Her latest book, Wittgenstein’s Ladder: Poetic Language and the Strangeness of the Ordinary, provides an opportunity for reflection on a body of writing remarkable both in its consistency and its constant reinvention. Indeed, reading Perloff (...) through Wittgenstein’s Ladder throws her other work over the last twenty years into a new light, as many concepts crucial to her vocabulary—not only theory but also modernism, artifice, avant-garde—are here turned around and forced into new roles. To ask whether and to what extent Wittgenstein’s Ladder constitutes a break in her career is simultaneously to raise the question of critical and poetic theory.Theory Inside and Out“It is in this sense that grammar may be said to replace theory,” writes Marjorie Perloff in the introduction to Wittgenstein’s Ladder [18]. The sense in question is Ludwig Wittgenstein’s, or rather the sense of the late (post-1929) Wittgenstein inflected through Perloff’s post-poststructuralist sensibility. As the sentence preceding this remarkable claim puts it: “For although the later Wittgenstein was to argue that grammar is precisely the key to understanding a given proposition, that there is no essence above and beyond a specific grammatical structure, one nevertheless must ‘distrust’ grammar in the sense of interrogating it as stringently as possible” [17–18].Of course, formulations of theory as a style of distrust have been a commonplace in theoretical discourse for some time. It would not be difficult to argue that Perloff’s explicit advocacy of grammar through Wittgenstein—whose philosophy, she argues, “is indeed intentionally ‘antiphilosophical,’ its purpose being precisely to determine in what circumstances philosophy should be ‘against’ philosophy and why” [12]—is of a piece with recent attempts to think the limits of theory in theory itself. But such a reduction would seriously misread Perloff’s project. We would do well to question, for example, the obvious similarities between Perloff’s description of a duplicity in the project of grammar/theory and the model it might be taken as at once pointedly evoking and evading, Paul de Man’s now-classic essay “The Resistance to Theory.” Despite their apparent similarities, the startling claims of Wittgenstein’s Ladder have little in common with de Man’s suggestion that “resistance may be a built-in constituent of [theoretical] discourse,” and that “the polemical opposition, the systematic non-understanding and misrepresentation, the unsubstantial but eternally recurrent objections, are the displaced symptoms of a resistance inherent in the theoretical enterprise itself” [12].For one thing, de Man explicitly distances his conception of a theoretical project deeply threatening to the claims of knowledge from one rooted in concepts of grammar: [End Page 67][A]s long as it remains grounded in grammar, any theory of language, includ-ing a literary one, does not threaten what we hold to be the underlying principle of all cognitive and aesthetic linguistic systems. Grammar stands in the service of logic which, in turn, allows for the passage to the knowledge of the world. The study of grammar, the first of the artes liberales, is the necessary pre-condition for scientific and humanistic knowledge. As long as it leaves this principle intact, there is nothing threatening about literary theory. The continuity between theory and phenomenalism is asserted and preserved by the system itself. Difficulties occur only when it is no longer possible to ignore the epistemological thrust of the rhetorical dimension of discourse, that is, when it is no longer possible to keep it in its place as a mere adjunct, a mere ornament within the semantic function.[14; emphasis added]In other words, de Man places grammar opposite the project of criticism, which he identifies with rhetoric and ultimately with reading. What de Man refers to as “the latent tension between rhetoric and grammar” is resolved decidedly in favor of the former: “the grammatical decoding of a text leaves a residue of indetermination that has to be, but cannot be, resolved by grammatical means, however... (shrink)

A recent debate over the causal foundations of evolutionary theory pits those who believe that natural selection causally explains long-term, adaptive population change against those who do not. In this paper, I argue that this debate – far from being an invention of several articles in 2002 – dates from our very first engagements with evolution as a quantified, statistical science. Further, when we analyze that history, we see that a pivotal figure in the early use of statistical methodology (...) in evolutionary theory, W.F.R. Weldon, changes his mind about precisely the central claim at issue. I close by drawing some morals which I think the case can offer for the contemporary debate going forward. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:EDWARD W. STRONG, 1901--1990 Edward W. Strong, one.of the founders and leaders of the Journal of the HistoryofPhilosophy,passed away on January 13, 199o, after a long struggle with cancer. Born in Dallas, Oregon in 19~ 1, he was eighty-eight years old when he died. He did his undergraduate studies at Stanford, receiving his B.A. in 1925. Then he went on to graduate studies at Columbia, where he received (...) a master's degree in 1927 and a Ph.D. in 1937. He taught at City College in New York from 1927 to 1932, and then began his long career at the University of California, Berkeley, where he remained for the rest of his academic life. During World War II, he became laboratory manager of the university's Radiation Laboratory (now called the Lawrence Berkeley Laboratory), which was part of the Manhattan Project to develop the atomic bomb. After the war, Strong became a full professor in 1947, chairman of the Sociology Department from 1946 to 1952, Associate Dean of the College of Letters and Sciences from 1947 to 1955, a leader of the Academic Senate and its Educational Policy Committee, and Chancellor of the Berkeley campus from 1961 to 1965.This was a period of very rapid growth for the campus as well as its most troubled time. When the student rebellion--the Free Speech Movement--broke out, Strong tried valiantly but unsuccessfully to preserve those academic values he felt most challenged. As the conflict wore on, he ceased to have the full support of his superiors, the President of the Universityand the Board of Regents, who negotiated a resolution with the students, the effects of which are still being felt at Berkeley and elsewhere in the United States. Some feel that Strong's position in the struggle that transformed American universities has not been properly understood, and that his role has been portrayed unfairly to enhance that of his superiors. In any event, he resigned as Chancellor and became Professor Emeritus in 1967. Strong developed his interest in the history of philosophy, history of science, and history of ideas at Columbia during its heyday as a center for such concerns, under the leadership of John Dewey and Frederick Woodbridge. He told me that he was also very much influenced by the historical interests of Morris Raphael Cohen, his senior colleague at City College. His dissertation, Proceduresand Methods,was, and still is, a basic study of the origin and development of modern science. (It was mentioned approvingly in an article by Ernst [9] 10 JOURNAL OF THE HISTORY OF PHILOSOPHY 29:1 JANUARY 1991 Cassirer, in 194o). In contrast to E. A. Burtt, whose MetaphysicalFoundationsof ModernPhysicalSciencestressed the philosophical and theological concerns of the early scientists, Strong emphasized the practical engineering concerns that were involved at the time. This led him to studies of Kepler, Galileo, and Newton, as well as to the scientific views of medieval thinkers, and modern views in the philosophy of science. Philosophically he was a naturalist, continuing the Columbia tradition. He was also very interested in Bergson's views, especially as they related to modern scientific ideas. He was the inspirer and founder of the History of Science discussion group at Berkeley, which became an important forum for creative research in this area. Strong was President of the American Philosophical Association in 1959. Because of the limited attention and concern given to the history of philosophy in most of the then-existing philosophicaljournals in America, the American Philosophical Association in 1957 approved in principle the establishment of a journal devoted to the history of philosophy, and appointed a committee of six members--Paul Kristeller, Gregory Vlastos, Richard McKeon, Julius Weinberg, John Goheen, and Edward Strong--to explore "ways and means to this end." Since all American philosophical journals at that time were published in the East and Midwest, Strong and Goheen were encouraged to try to establish the journal in the West. Strong has detailed the efforts to do this in his article, "The Founding of theJournal oftheHistoryofPhilosophy,"Journalof theHistoryofPhilosophy~5 (1987): 179-83. I first met Ed Strong at Trinity College, Dublin, in the summer of 1953, when I was a... (shrink)

The Dutch law states that a physician may perform euthanasia according to a written advance euthanasia directive when a patient is incompetent as long as all legal criteria of due care are met. This may also hold for patients with advanced dementia. We investigated the differing opinions of physicians and members of the general public on the acceptability of euthanasia in patients with advanced dementia.

Public health emergencies, such as the Covid-19 pandemic, put great pressure on healthcare workers (HCW) across the world, possibly increasing the risk of experiencing ethically challenging situations (ECS). Whereas experiencing ECS as a HCW in such situations is likely unavoidable, mitigation of their adverse effects (e.g., moral distress) is necessary to reduce the risk of long-term negative consequences. One possible route of mitigation of these effects is via work environmental factors. The current study aimed to examine: [1] risk factors (...) associated with ECS among HCW [2], intensity of moral distress associated with ECS across various occupational factors (i.e., profession, degree of exposure to patients with Covid-19), and [3] the impact of work environmental factors on this association, in a sample of HCW during the pandemic. We employed multiple logistic and linear regression to self-report data from 977 HCWs at four Norwegian hospitals responding to a survey at the fourth wave of the pandemic. About half of HCW in this study had experienced ECS during the pandemic, and levels of moral distress associated with such were higher than in previous studies using similar assessment methods. Younger age, female sex, geographical work area (mid-north of Norway), and profession (nurse) were all associated with higher odds (range of OR: 1.30–2.59) of experiencing ECS, as were direct contact with patients with Covid-19. Among those participants who reported that they had experienced ECS during the pandemic, moral distress levels when recalling those situations were moderate (Mean 5.7 on a 0–10 scale). Men reported somewhat lower intensity of moral distress (partial eta squared; ηp2 = 0.02). Reporting a manageable workload (ηp2 = 0.02), and greater opportunity to work according to best practice (ηp2 = 0.02), were associated with lower levels of moral distress. Our findings suggest that moral distress could potentially be mitigated on an organizational level, particularly by focusing on ensuring a manageable workload, and an ability to work according to best practice. To build sustainable healthcare systems robust enough to withstand future public health emergencies, healthcare organizations should implement measures to facilitate these aspects of HCWs’ work environment. (shrink)

If stem cell-based therapies are developed, we will likely confront a difficult problem of justice: for biological reasons alone, the new therapies might benefit only a limited range of patients. In fact, they might benefit primarily white Americans, thereby exacerbating long-standing differences in health and health care.

Frege: Philosophy of Language has been heralded as Michael Dummett's long-awaited magnum opus on Frege. Actually, however, as the author himself tells us, it is only the first of a two-volume series devoted to Frege's philosophy of language and his philosophy of mathematics respectively.The book itself has been long in preparation, the writing of it having been interrupted for several years. This fact could not help but leave some marks on the organization and content of the various chapters. (...) Still, all in all, it presents a remarkably interesting and provocative whole. It is topical, rather than purely genetic in approach, dealing with various fundamental features of Frege's philosophy of language in some 19 chapters; e.g., with his sense-reference distinction, his theory of assertions, his conception of the nature and place of truth-values, propositions and thoughts, his views on quantification and identity, the nature of proper names, his polemic about explicit vs. implicit definitions, his theory of incomplete expressions, and the like. However, the historical needs of the reader are also well-served. (shrink)

A total of 1918 loci, detected by the hybridization of 938 expressed sequence tag unigenes from 26 Triticeae cDNA libraries, were mapped to wheat homoeologous group 4 chromosomes using a set of deletion, ditelosomic, and nulli-tetrasomic lines. The 1918 EST loci were not distributed uniformly among the three group 4 chromosomes; 41, 28, and 31% mapped to chromosomes 4A, 4B, and 4D, respectively. This pattern is in contrast to the cumulative results of EST mapping in all homoeologous groups, as reported (...) elsewhere, that found the highest proportion of loci mapped to the B genome. Sixty-five percent of these 1918 loci mapped to the long arms of homoeologous group 4 chromosomes, while 35% mapped to the short arms. The distal regions of chromosome arms showed higher numbers of loci than the proximal regions, with the exception of 4DL. This study confirmed the complex structure of chromosome 4A that contains two reciprocal translocations and two inversions, previously identified. An additional inversion in the centromeric region of 4A was revealed. A consensus map for homoeologous group 4 was developed from 119 ESTs unique to group 4. Forty-nine percent of these ESTs were found to be homoologous to sequences on rice chromosome 3, 12% had matches with sequences on other rice chromosomes, and 39% had no matches with rice sequences at all. Limited homology was found between wheat ESTs on homoeologous group 4 and the Arabidopsis genome. Forty-two percent of the homoeologous group 4 ESTs could be classified into functional categories on the basis of blastX searches against all protein databases. (shrink)

This volume brings together eleven essays that address a range of issues extending from broader questions of social justice to the sexual intimacy that bears the mark of our fleshly existence. Collectively, these essays extend the reach of Paul Ricoeur’s early to late works by taking up some of the major social, political and religious challenges facing us in a postmodern, ultrapluralistic world.

Normal 0 false false false EN-US JA X-NONE Normal 0 false false false EN-US JA X-NONE The spotlight that Martha Nussbaum turns on the plight of women in developing nations brings the disproportion between human capabilities and the opportunities to exercise them sharply into focus. Social prejudices, economic discrimination, and deep-seated traditions and attitudes all harbor the seeds of systemic injustices within governing policies and institutions. The refusal on the part of a dominant class to recognize the rights and claims (...) of subaltern individuals and groups has both symbolic and material consequences. The power that one group exercises over another brings the refusal to recognize the rights and claims of others to the fore. Thanks to the moral priority that Paul Ricoeur accords to the victim against such refusals, I tie the fragility of identity to the idea of justice’s federating force. This federating force, I therefore argue, accompanies the struggle for recognition among capable human beings. (shrink)